Evolving Health

Monthly Archives: February 2009

As evident by many sugar-laden soda pop “potbellies” of North America, lipogenesis can obviously occur from drinking and eating too much sugar (1). Wouldn’t it be just grand to reverse the process and be able to lose all that fat via gluconeogenesis? Unfortunately mammals do not have the ability to synthesize glucose from fats (1). The fact is that once glucose is converted to acetyl coA there is no method of getting… Read More

Normally what you need before you can start up aerobic respiration in the mitochondria is a multienzyme complex known as pyruvate dehydrogenase complex—of which the main enzyme is pyruvate decarboxylase. The complex acts on pyruvate, produced from glycolysis, in an oxidative decarboxylation reaction to produce acetyl-coA, which then enters the citric acid cycle (1). What happens when pyruvate dehydrogenase is deficient? An actual genetic deficiency is rare, but it is the most… Read More

Almost half of us will die of a heart attack or stroke; in fact, it’s likely many of us have been developing a type of cardiovascular disease already (1). Just being male increases your risk, and if you happen to be a male, sedentary, obese smoker then you’re in real trouble (1). Adding these risk factors up doesn’t triple your chances, it multiplies them seven-fold (1)! In light of American Heart Month,… Read More

It’s interesting to note that contraceptives can increase risk of thrombosis. A report in 1980 showed that two women who died of myocardial infarction did not smoke or have hyperlipidemia, hypertension or atherosclerosis; the only connection was an oral contraceptive (1). I’d like to learn more about why this would happen. 1. Loire R, Touboul P, Gressard A, Rondepierre D, Tabib A. [Oral contraceptive and coronary thrombosis. Two clinicopathological cases]. Arch Mal… Read More

Next time you’re on a long car trip, check your legs to see if one is redder or warmer than the other. Or if your calf or thigh begins to ache. These could be symptoms of deep vein thrombosis, especially if you’re genetically predisposed. Inactivity can cause the condition and blood thinners like heparin or warfarin are generally used as treatment (1). But while we understand that hypercoagulation can be a factor… Read More

When a blood vessel is injured, a coagulation cascade is activated to form an organized clot to retain moisture and begin a healing process. Unlike a clot, a thrombus occurs in the blood vessel as a result of endothelial damage, altered blood flow or a hypercoagulation state that triggers platelet activation and a coagulation cascade (1). About one in 1,000 adults develop thrombosis annually (2). Endothelial damage Contributing to risk of thrombosis,… Read More

Unlike other nations where food and culture are intertwined and make up the diets of most people, here in the U.S. we have more diet books than we can read. Along with these come dietary philosophies that absolutely nothing to do with the exact science of true nutrition. Obsession has a way of skewing fact and fiction merging them into a new viewpoint of the world that is borderline fantasy. A concern… Read More

Sickle cell anemia is a genetic blood disorder that occurs when production of red blood cells contain abnormally shaped hemoglobin that, in effect, also distort red blood cells making them look crescent-shaped or “sickle-like” (1). The hemolytic condition occurs because these cells have a lifespan of about 20 days versus the normal cell lifespan of 120 days; the marrow and spleen clear them out early leading to a low count in total… Read More

Do you feel tired and weak all the time? You should find out if you have pernicious anemia. The blood disorder occures when you can’t make enough red blood cells to take oxygen to your cells due to lacking B12. Lack of B12 in the diet may be due to lack of intrinsic factor. To understand how this might happen, it’s important to understand just how cobalamin is absorbed. Cobalamin (B12) is… Read More

The last time my wife saw her father, she was nine years old. He left  to the hospital to have some general blood tests done. His doc had told him he had symptoms of a blood disorder: pale skin, frequent nose bleeds and bleeding gums, frequent infections, weight loss, fever, poor appetite and extreme fatigue. To rule out leukemia, a full blood count was used to determine how many cell types were in… Read More