Understanding Pernicious Anemia

Intrinsic factor, a glycoprotein secreted from paretal cells in the stomach, is responsible for forming a complex with cobalamin (B12) to then bind to an ileal receptor for absorption (1p1184). Lack of ability to secrete intrinsic factor results in pernicious anemia, a megaloblastic anemia from cobalamin deficiency(1;2). Pernicious anemia therapy often requires parenteral cobalamin or oral cobalamin in high enough doses (1).

Identifying megaloblastic anemia in a Complete Blood Count:

RBC – Decreases
Hb – Decreases
MCV – Increases
MCH – Stays the Same
MCHC – Stays the Same

(3)

Reference List

1. Modern Nutrition in Health and Disease. Baltimore, MD: Lippincott Williams & Wilkins, 2009.
2. Saladino, C. “Week 1 Lecture, Part 1.” Clinical Biochemistry [Lecture Series], 2009.
3. Medicine.net. “Complete Blood Count”. Available at http://www.medicinenet.com/complete_blood_count/article.htm. Accessed on June 06, 2009.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: