Tidbit: GLUT6 – the "pseudogene"

GLUT6 is expressed in various tissues in the body, but doesn’t encode any functional glucose transport protein (1). Why does it occur at all? It’s thought that GLUT6’s nucleotide sequence may have simply occurred from an insertion of GLUT3 reverse transcribed in a region of an untranslated gene (1).

Reference List

1. Kayano T, Burant CF, Fukumoto H et al. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J Biol Chem 1990;265:13276-82.


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: