Resveratrol-Rich Plant Extract Stifles Inflammation in Humans

Resveratrol’s antioxidant and anti-inflammation actions shown previously only in vitro and in laboratory animals have now been observed in a small human study.

State University of Buffalo New York and Kaleida Health researchers found that supplementation with a plant extract containing resveratrol suppressed generation of free radicals called reactive oxygen species (ROS) and reduced expression of two major proinflammatory pathways.

Writing in their study, published in Journal of Clinical Endocrinology and Metabolism, the researchers state that they have demonstrated for the first time in humans “comprehensive effects on ROS generation and inflammation” and the “antiaging action of resveratrol.”

In the trial, two groups of 10 healthy adults were randomized to receive placebo or 200 milligrams of Japanese knotweed extract (Polygonum cuspidatum) supplying 40 milligrams of resveratrol daily. Fasting blood samples were collected before, during and after six weeks of supplementation. Subjects chosen were not on any antiinflammatory drugs.

The researchers’ data showed clear suppression of ROS generation and reduced expression of TNF-alpha and IL-6, which are regulated by NFkB, that led to falling levels of C-reactive protein, which are all involved with inflammatory response.

In parallel, the extract reduced expression of two major proinflammatory enzymes, JNK-1 and IKK-beta.

Resveratrol’s effects on reducing oxidative stress and inflammation are thought to take place because it activates production of SIRT1, one of a family of proteins that is positively associated with influencing fat metabolism, slowing aging, and extending lifespan in response to calorie restriction and fasting in yeast and animals.

Chronic oxidative stress and inflammation are implicated as factors that accelerate aging because of damage caused to cellular components including membranes, mitochondria and DNA.

Source: Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. An Antiinflammatory and Reactive oxygen Species Suprressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol. J Clin Endocrin Metab. 2010; 10:12.

Published by David Despain, MS, CFS

David is a science and health writer living on Long Island, New York. He's written for a variety of publications including Scientific American, Outside Online, the American Society for Nutrition's (ASN) Nutrition Notes Daily, and Institute of Food Technologists' (IFT) Food Technology magazine and Live! blog. He's also covered new findings reported at scientific meetings including Experimental Biology, AAAS, AOCS, CASW, Sigma Xi, IFT, and others on his personal blog "Evolving Health." David is also an active member of organizations including the National Association of Science Writers (NASW), the American Association for the Advancement of Science (AAAS), the American Society for Nutrition, the Institute of Food Technologists, and the National Audubon Society. David has a master's degree in human nutrition from the University of Bridgeport, and a bachelor's degree in English from University of Illinois at Springfield. He also earned his Certified Food Scientist credential from the Institute of Food Technologists.

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