How lutein and zeaxanthin earned the limelight

When light enters the human eye it passes through the cornea, pupil, and lens to focus on an area of light-sensitive tissue called the retina. Near the center of the retina of the eye is a light yellow spot called the macula. It’s here where lutein and zeaxanthin concentrate to form macular pigment to filter out excessContinue reading “How lutein and zeaxanthin earned the limelight”

Is long-term calorie restriction in humans worth it?

Nearly 78 years have passed since the first experiment in the Journal of Nutrition was published that found that the restriction of calories without undernutrition would retard aging and prolong the mean and maximal lifespan of rats. That pioneering work of Clive M. McCay, Mary Crowell, and L. A. Maynard of Cornell led to several subsequentContinue reading “Is long-term calorie restriction in humans worth it?”

Nevermind body fat; put focus on muscle with age

With all the attention given to body fat, a result of the high prevalence of obesity and type 2 diabetes, skeletal muscle is often given the back seat. Yet holding on to lean muscle mass alone, in itself, may be the most important factor in avoiding health problems above. What’s often forgotten is that skeletal muscle is aContinue reading “Nevermind body fat; put focus on muscle with age”

Depression and telomeres

Reference: Wolkowitz et al. 2011 March. People who suffer from major depression have a higher risk of age-related illness and earlier mortality (1 &2). Researchers from University of California, San Francisco (UCSF), investigated (1) telomere length in depressed individuals versus matched controls and assessed other biological factors associated with telomere shortening. Led by Nobel laureateContinue reading “Depression and telomeres”

Safe weight loss for seniors through diet and exercise

In the United States, the number of obese older adults has reached disturbing heights—now affecting approximately 20 percent of those ages 65 and older—and is only expected to rise as more Baby Boomers become senior citizens. Weight loss through calories reduction or exercise are generally good for most people as an intervention in obesity, althoughContinue reading “Safe weight loss for seniors through diet and exercise”

Living longer with an ideal BMI

Maintaining a healthy body mass index, or BMI, is one of the most important ways to help you live longer, according to a new study published in the December issue of New England Journal of Medicine. BMI is not a perfect measure, but it is one of the simplest for estimating body weight. It isContinue reading “Living longer with an ideal BMI”

Aubrey de Grey Response to Rose and Coles

Aubrey de Grey Next up at H+ @Caltech this afternoon was the famous and fast-talking Aubrey de Grey, who provided a response to previous talks by Michael Rose and Stephen Coles. This is my take as how I understood the arguments. It was, admittedly, a bit hard to follow. What we heard from Rose andContinue reading “Aubrey de Grey Response to Rose and Coles”

Building Methuselahs

Michael Rose, evolutionary biologist Michael Rose is an evolutionary biologist, of University of California at Irvine, who knows how to sum up the complexity of aging. He told us at H+ @ Caltech that aging is just a normal process of natural selection. It’s obviously a “big picture” view versus a cellular or molecular view. ButContinue reading “Building Methuselahs”

Is there a maximum human lifespan?

Stephen Coles “Death is an imposition on the human race and can no longer be tolerated” – Alan Harrington With Harrington’s quote, Stephen Coles opened his talk on whether or not there is a maximum limit to human lifespan at H+ @ Caltech in Los Angeles. As a biogerontologist, Coles studies old people, as well as old yeast, microscopicContinue reading “Is there a maximum human lifespan?”

What can beetles tell us about slowing aging? Answers are in the mitochondria

Mitochondrial genes influence life expectancy in beetles, a new study reports. Genetic research into aging and longevity revolves mainly around the nuclear genome, which encodes most of our multicellular bodies, but a new Monash University study performed on beetles suggests shifting focus to the mitochondrial genome.   The mitochondria—kidney-shaped organelles often referred to as theContinue reading “What can beetles tell us about slowing aging? Answers are in the mitochondria”