Iron Man

Iron is abundant in the world and needed by every living organism. For this reason early in evolution multi-cellular organisms evolved antimicrobial peptides(1). Without them we just wouldn’t be able to survive the onslaught of microbial growth (1). In addition, free iron in plasma has redox capabilities that can also be toxic. The toxicity isContinue reading “Iron Man”

Assessment: Fish Consumption and Incidence of Stroke Meta-Analysis

Purpose of review: Further research was necessary into relationship between fish consumption and risk of stroke because observational studies were inadequate for determining relationship. Review strategy: Meta-analysis on cohort studies relating to fish consumption and risk of stroke. Description: Researchers searched Medline and Embase databases with relative keywords (e.g. “fish) to identify 9 total relevantContinue reading “Assessment: Fish Consumption and Incidence of Stroke Meta-Analysis”

Understanding Pernicious Anemia

Intrinsic factor, a glycoprotein secreted from paretal cells in the stomach, is responsible for forming a complex with cobalamin (B12) to then bind to an ileal receptor for absorption (1p1184). Lack of ability to secrete intrinsic factor results in pernicious anemia, a megaloblastic anemia from cobalamin deficiency(1;2). Pernicious anemia therapy often requires parenteral cobalamin orContinue reading “Understanding Pernicious Anemia”